3D-printed inserts bring single-objective light sheet microscopy to commercial sample chambers

What happened

Rice University's Anna-Karin Gustavsson has published a method in Nano Letters that expands the use of light sheet microscopy to work with a single objective in commercially available sample chambers. Light sheet microscopy allows biologists to selectively light up a thin slice of a sample. This method can improve image contrast by reducing background light while remaining gentle on the sample, reducing photodamage and photobleaching.